Somashekhar M Metri*, Anil Metre, Basavraj D, R B Kotnal
We have chosen molecule having moieties possessing antimicrobial activity of pyridine has been derived from benzene and its structure might be obtained by replacing a -CH moiety with a nitrogen atom. Which is reported to have antibacterial and anti-tubercular activity and other pyridine ring attached to fourth position of the benzene ring which possesses the antibacterial activity Present work deals with the preparation of pyridine 3-carboxylic acid in ethanol and thionyl chloride refluxed gives 2- {-5 pyridine-3-yl)-1, 3, 4- oxadiazole-2-yl) sulfonyl} acetohydrazide) with various substituted aromatic aldehyde and heterocyclic compound to form pyridine derivatives. Hydrazides were synthesized so as to increase intracellular concentration and so as to try and decrease the resistant developed due to decrease intracellular concentration of the drug these synthesized compounds were subjected to preliminary biological evaluation. The characterization of synthesized compounds was identified on the basis of IR, 1HNMR, Mass spectroscopy. The compounds have been evaluated for antimicrobial activity.
