Mohd. Jishan Khan, Vipin Saini, Varun S. Bhati, Manvendra S. Karchuli, Sanjay B. Kasture
The present study was carried out to investigate the anxiolytic activity of Ipomoea aquatica leaves. The shade dried leaves were extracted successively with petroleum ether and methanol: acetone (MAE-IA). The total flavonoids contents were determined as 200 mg/kg of dried plant material. The anxiolytic activity of MAE-IA was evaluated using elevated plus maze, light: dark apparatus, hole board apparatus. Its ability to influence ketamine-induced sleep was also assessed in mice. The MAE-IA (200 & 400 mg/kg orally) increased: time spent in open arm of elevated plus maze, time spent in lit area of light: dark apparatus and number of head poking in the hole board apparatus. The extract also increased duration of ketamine-induced sleep. The observations suggest anxiolytic activity of Ipomoea aquatica leaves.
