Insights in Analytical Electrochemistry Open Access

  • ISSN: 2470-9867
  • Journal h-index: 8
  • Journal CiteScore: 1.52
  • Journal Impact Factor: 1.49
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Reach us +32 25889658

Abstract

Application of Analytical Chemistry and Bioanalytical Chemistry

Gary F Massart

Bile Acids (BAs) constitute an important class of biological molecules produced in the metabolism of all vertebrates. In mammals, they exhibit the so called C24 structure: 24 carbon atoms form a steroid nucleus (three six-member rings indicated as A, B C and a five-member ring indicated as D) and a fivecarbon side chain with a carboxyl group at the C-24 position. The A and B rings are linked in cis configuration, inducing an overall bent shape. Such a structural feature delineates a concave and convex side of the steroidal backbone where OH groups in α orientation (up to three) and two methyl groups in β orientation, respectively, point out. Therefore, two opposite faces with hydrophilic and hydrophobic properties can be distinguished. Further variations of the molecular structure can be observed at C-3 carbon due to hydroxyl, sulfate or glucuronate substituents. C-6 and C-24 glucoronide conjugates were also found in humans. Other C-24 substituents are glycine or taurine.

Published Date: 2021-11-25; Received Date: 2021-11-03