Rui Wang*
Exogenous and endogenous DNA may trigger the Pathogen-Associated Molecular Pattern (PAMP) during infection and the Danger-Associated Molecular Pattern (DAMP) that senses intracellular DNA, thereby activating the evolutionarily conserved cGAS-STING mechanism for inflammatory reactions. The cGAS-STING signaling cascade plays a crucial role in the pathogenesis and progression of numerous clinical conditions, including neurodegenerative, autoimmune, cardiovascular, and neoplastic conditions. Inhibition of cGAS-STING signaling is effective in treating the first three conditions, but there is controversy regarding whether cGAS-STING should be suppressed or activated in cancer therapy. Deregulation of the cGAS-STING signaling pathway may be the cause and pathogenesis of a variety of pathological conditions; therefore, understanding and modulating cGAS-STING signaling holds tremendous promise for treating a wide range of diseases.
Published Date: 2025-01-17; Received Date: 2023-07-28
