Ansari S, Yadav N, Das S, Thapa NK and Kuppuram GB
Introduction: The pandemic COVID-19 has emerged from Wuhan city of China in December 2019 and now spread all around the world till the end of March 2020. The World Health Organization (WHO) has named this corona virus disease as COVID-19 and defined it as the disease caused by severe acute respiratory syndrome corona virus -2 (SARS-CoV-2). Aim: The aim of this study was to find out a possibility for the treatment of a patient infected with SARS-CoV-2 (COVID-19) using high energy ionizing radiation, 10-15 MV X-ray photon, based on biological facts and scientific evidences. Materials and Methods: RNA is the integral part of SARS-CoV-2. And it is wellknown fact that high energy ionizing radiation is able to break strand of both RNA and DNA causing cell death. SARS-CoV-2 enters into host cells using spikeglycoprotein consists of a large ectodomain. The ectodomain contains a receptorbinding unit S1 and a membrane-fusion unit S2. Results: Severalstudiesshowed thatthere are basic similaritiesin chemical bonding of base of RNA and DNA. Adenine, Guanine, Cytocine and Uracil are common and identical components. These common components have weak hydrogen bonds. Single-stranded RNA (ss RNA) is the major structural component of SARS-CoV-2. Discussion: The pandemic COVID-19 has panicked the world. There is no clinically approved medicine for this deadly disease up till now in the medical science. Only symptomatic treatment is given to the patients. On analyzing the several studies and literatures related to radio-biology, molecular biology, virology and radiation oncology, our medical physicist team found that DNA and RNA have many identical and common features. And high energy ionizing radiation (IR) is capable to break the strand of RNA, spike-protein, lipids and kill the viruses. Conclusion: High energy ionizing radiation has a peculiar capability to damage the strand of RNA, proteins and lipids which are the integral parts of SARS-CoV-2. It is able to break the bond between ACE-2 of host cell and Spike- protein of SARSCoV-2. Hence, it is concluded that 10-15 MV X-ray photon should be used for the treatment of patientsinfected with SARS-CoV-2 and it willsurely give better result.
