Y. Surekha, P. Venugopalaiah, K. Gnan Prakash and M. Gobinath
Oral modified release multiple unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single unit dosage forms. The present study is to prepare Rabeprazole sodium delayed release pellets by using HPMC based sub coating and Methacrylic acid copolymer based enteric coating and to target the release of drug in intestine and to avoid stability related problems. Different batches of pellets were prepared by using drug suspension method. Comparative study of dissolution profile of final batch with market preparation was conducted and it was concluded that final batch shown good similarity with market product. The results of the accelerated stability of final formulation revealed that storage conditions were excellent.
