V. Madhava Reddy Papasani, N. Lal Mahammed and P. Sireesha
The objective of the study was to invistigate the effect of Irbesartan and rutin in High Fructose Corn Syrup (HFCS) plus alcohol induced Insulin Resistance Syndrome in rats. Our study demonstrated the beneficial effects of Irbesartan and rutin on both abnormal metabolic characters and vascular dysfunction in insulin resistant rats. Initially we have validated the predaibetic Insulin Resistance Syndrome rat model by feeding High Fructose Corn Syrup to the male Sprague Dawley rats. Development of Insulin Resistance Syndrome and glucose intolerance was assessed by performing the plasma biochemical analysis such as plasma glucose, triglyceride, insulin and total cholesterol levels. Glucose intolerance was assessed by performing an intraperitoneal glucose tolerance test. And Histopathological studies of Liver were conducted. In the present study, we examined the effect Irbesartan and rutin and the relationship between the plasma adiponectin concentration and adiposity, body fat distribution, lipid profile, renal profile, liver enzymes, Cardio vascular parameters, histopathology of Liver, in High Fructose Corn Syrup fed Sprague-dawley rats. It was concluded that Irbesartan and rutin are effective in treating Insulin Resistance Syndrome and alcohol induced liver toxicity Further studies are needed to explore the underlying mechanisms.
