Amanda Sarita Cruz Aleixo1*, Mayra de Castro Ferreira Lima1, Ana Luísa Holanda de Albuquerque1, Raphael Tortorelli Teixeira1, Renata Alves de Paula1, Marina Cecília Grandi2, Danilo Otávio Laurenti Ferreira3, Viviane Maria Codognoto1, Henry David Mogollón García1, Miriam Harumi Tsunemi4, Eunice Oba1, Fabiana Ferreira de Souza1,2, Simone Biagio Chiacchio 1 and Maria Lucia Gomes Lourenço1
Objective: The objectives of the study were to evaluate the behaviour of electrocardiographic parameters in lambs during development and the concentrations of maternal and neonatal cardiac biomarkers NT-proBNP and troponin I. These results significantly contribute to medical research, since the sheep heart is similar to the human heart.
Methods: Ten Dorper lambs were evaluated after birth until 120 days of age. A computerized electrocardiographic was performed from the record of six leads. The determination of NT-proBNP was performed by the ELISA method, the troponin I was performed by the ELFA technique with a Vidas® Troponin I Ultra kit.
Results: The HR decreased at 21 days of age, and the PR interval was elevated after that period. The P-wave had a longer duration at 90 and 120 days of life. There was no difference in the duration of the QRS complex across the age groups. The duration of the QT interval increased from 30 days of age, the duration of the T-wave increased from 21 days, and its amplitude was increased from 24 hours after delivery up to 7 days of age. There were no differences in the concentrations of the maternal and lamb biomarkers in any of the evaluated periods.
Conclusion: From 21 days, there was a reduction in HR, which illustrates the participation of the ANS and the balance between vagal and sympathetic activities in this age group. Thus, as development progresses, there are changes in cardiac electrical conduction. The cardiac biomarkers NT-proBNP and troponin I do not change during development.
