Ashesh Kumar Chowdhury
Presence of several criteria for metabolic syndrome and lack of uniformity among them create confusion among the physicians during diagnosis. We estimated serum levels of adiponectin, soluble CD36 and hs-CRP in patients with metabolic syndrome and to see the variation of their levels in comparison to those of a group of healthy subjects. A total of 180 subjects were enrolled in this cross-sectional study. 120 of them met the criteria of ‘consensus definition’ for metabolic syndrome and 60 of them were healthy subjects without metabolic syndrome. Statistically significant difference was found in serum level of adiponectin (10.38 ± 5.09 vs 20.87 ± 8.23 ng/ml, p= <0.001), soluble CD36 (4.6 ± 2.93 vs 3.75 ± 1.68 ng/ml, p <0.001) and hs-CRP (3.26 ± 4.73 vs 3.23 ± 0.00 mg/dl, p= 0.002) between metabolic syndrome patients and healthy subjects. It also revealed significant difference in adiponectin (11.6 ± 4.32 vs 20.87 ± 8.32, p= 0.013) and soluble CD36 (4.20 ± 2.09 vs 3.75 ± 1.68, p= 0.006) level between diabetic and non-diabetic group of metabolic syndrome. Adiponectin level showed significant relation with most of the (4 out of 5) parameters of metabolic syndrome (waist circumference [WC] (r= -0.651, p <0.001), systolic blood pressure [SBP] (r= -0.385, p<0.001) and diastolic blood pressure [DBP] (r= -0.510, p<0.001), triglyceride (TG) (r= -0.253, p=0.024) and high density lipoprotein [HDL] (r= 0.256, p= 0.022)). Soluble CD36 showed positive significant relation with 3 parameters (WC (r= 0.345, p= 0.002), TG WC (r= 0.275, p= 0.014) and (DBP (r=0.361, p=0.001).
