Brusgaard Klaus* and Burton Mark
Garlic has shown many and diverse beneficial effects on health. Focus has been on which compounds have effect. We analyze the transcriptional consequences of digesting limited amounts of raw garlic and analyze the overall outcome. This study focuses on the reported health related effects of garlic digestion in relation to the observed transcriptional changes to identify and understand the eventual casual outcome. We utilize a non-hypothesis driven global approach to analyze the transcriptional consequences of eating moderate amounts of garlic in a group of young people. Unsupervised principal component´s analysis and heat maps showed changesin gene expression of RNA extracted from peripheral blood using microarrays. Pathway analysis was performed using gene set enrichment analysis with KEGG, Reactome and Gene Ontology defined gene sets asinput. A number of significant pathway changes were observed. When correcting for gender difference a possible relation to beneficial effects observed in both men and women were observed. Especially the gender specific immune dimorphism upon garlic digestion Our results support the notion of a link between olfaction, neurology and the immune system and imply that a common mechanism explainsthe link between garlic ingestion and the previous reported pleiotropic positive effects.
Published Date: 2023-08-29; Received Date: 2023-08-01
