Evalution activity Cisplatin infection by leishmanasis invivo and invitro and
study of the associated histological changes in mice balb / C

Athraa Abd-Al Ameer-Aziz- Al-Hilfy

Abstract

Evalution activity Cisplatin infection by leishmanasis invivo and invitro and study of the associated histological changes in mice balb / C

Athraa Abd-Al Ameer-Aziz- Al-Hilfy

The current study included evaluation of the effectiveness of the drug Cisplatin vital phase promastigote leishmaniasis parasite inside and outside the living body, and its effects on the liver and kidney in laboratory mice balb/c. This study proved that the drug Cisplatin highly effective in killing phase promastigotein vitro, which reached a maximum of 100% on the fourth day when the drug concentration (0. 4 mg / mL). Histological study showed that infection caused histologic changes different intensity of the liver while changes were less severe in mice infected and drug treatment as well as with the kidney