Suresh Devshi Sanja, Kilambi Pundarikakshudu and Moinuddin Maqsud Soniwala
Eclipta alba Hassk. (Bhringaraja, Fam: Compositae) is a perennial shrub which grows widely in moist tropical countries. Different uses have been reported for this shrub. It is used as anthelmintic, expectorant, antipyretic, antiasthmatic, tonic, deobstruent in hepatic and spleen enlargement, in skin diseases and as a substitute for Taraxacum (a popular liver tonic). It has been reported to be useful in liver ailments and has been shown to possess hepatoprotective activity against carbon- tetrachloride induced liver cell damage in animals. The aim of the present study was to design and estimate gastro retentive floating tablet of selected hepato-protective herbal drugs to increase the efficacy and stability of the drug. The floating tablet of extract of Eclipta alba was prepared by using kollidon SR as floating and release retarding polymer. The effect of various additive excipient was also studied to alter the floating behaviour and drug release from the floating tablet.
