K. Kranthi Kumar, Dr. L. Srinivas, Dr. V. Sai Kishore and S. Naseeb Basha
Febuxostat is a urate lowering drug, an inhibitor of xanthine oxidase used in the treatment of hyperuricemia and chronic gout. The drug shows dissolution-rate limited absorption, there by poor and variable bioavailability. It needs enhancement in bioavailability to derive maximum therapeutic efficacy. The main objective of the present research work is to enhance the solubility and dissolution rate of Febuxostat by preparing the Spherical agglomerates. Spherical agglomerates were prepared by the quasi emulsion solvent diffusion method. N, N-dimethyl form amide, chloroform and water were selected as good solvent, bridging liquid and poor solvents respectively. Polyethylene glycol, Poloxomer- F68 and Polyvinyl alcohol were used as a carrier. Among all the formulations prepared, spherical agglomerates prepared with Febuxostat and Poloxomer- F68 in 1:1 ratio showed highest drug release in 60 minutes. Spherical agglomerates prepared with Febuxostat and Poloxomer- F68 in 1:1 ratio was used in the preparation of orodispersible tablets. To study the influence of superdisintegrants on performance of Febuxostat Orodispersible Tablets, a set of three formulations (K1, K2, K3) were prepared using three superdisintegrants sodium starch glycolate, Croscarmalose sodium and Crospovidone . The orodispersible tablets of Febuxostat prepared with Crospovidone showed rapid drug release when compared to pure drug and other tablet formulations.
