Both oncologists and pathologists have acknowledged that the broad histologic classifications, particularly for
ovarian and endometrial carcinomas, do not consistently separate groups with comparable clinical trajectories or
therapeutic response patterns. When the findings from the Cancer Genome Atlas (TCGA) project were released
during the previous decade, a paradigm shift was triggered. Instead of the two subtypes proposed by Bokhman
in the 1970s, extensive genomic profiling data from TCGA has revealed that there are four molecular subgroups
of endometrioid carcinomas.
Published Date: 2022-06-27; Received Date: 2022-05-31
