In Humans, Do THP-1 Monocytes and Macrophages, and Resveratrol Affect Immune Responses Differently?

Swapna Sanika

Abstract

In Humans, Do THP-1 Monocytes and Macrophages, and Resveratrol Affect Immune Responses Differently?

Swapna Sanika

Resveratrol (Res), an herbal polyphenol compound discovered in grapes and pink wine, has been proven to show off antiinflammatory, antioxidant, and anticarcinogenic consequences. However, proinflammatory/tumor-selling residences of Res have additionally been reported, rendering the polyphenols reported healing advantages much less convincing and controversial. To examine the underlying workable elements contributing to the differential immunomodulatory consequences imparted through Res, herein, we investigated, at each physiological and pharmacological dose, the in vitro consequences of Res on mobileular survival/proliferation, inflammatory genes, and cytokine manufacturing in human monocytic mobileular line (THP-1) and phorbol 12-myristate 13-acetate differentiated human THP-1–derived macrophages.