Tingting Gao1,2 , Chunfang Ha2 , Ping Yin3 , Qing Zhang4 , Yongchao Huang5 , Young Dai5 , Serdar E. Bulun3 and Jian-Jun Wei1,3
Leiomyoma with bizarre nuclei (LM-BN) is a rare uterine smooth muscle tumor characterized by a remarkable nuclear atypia reminiscent of its malignant counterpart leiomyosarcoma (LMS). While it presents with an overall benign clinical course, the biological nature and pathogenesis of LM-BN remains largely unknown. The controversy about the r?ů??ŽnƐ?ŝ? between LM-BN and benign and malignant uterine smooth muscle tumors remains unresolved. To date, the diagnosis of LM-BN relies mainly on morphological c??r?c??rŝƐ?cƐ? and no ?ī?c??? molecular markers have been established. Here we describe and summarize recent progress in understanding this unique tumor ?n??y? with a focus on new Įn?ŝnŐƐ regarding molecular and genomic ?ů??r??ŽnƐ and the ?Ž??n??ů r?ů??ŽnƐ?ŝ? of LM-BN with LMS.
