Mohan Vangala, Prabhakar Reddy Veerareddy, Venkat Ratnam Devadasu and Sateesh Kumar Vemula
The current study was aimed to develop the meclizine hydrochloride sublimated fast dissolving tablets using different sublimated agents to enhance the dissolution rate. The prepared fast dissolving tablets were subjected to pre-compression properties and characterized for hardness, weight variation, friability, wetting time, water absorption ratio, and disintegration time. From In vitro dissolution studies, the formulation F3 containing camphor (10%w/w) as the sublimating agent showed rapid dissolution of about 98.61% in 30 min, and disintegration time 43 sec when compared with other sublimating agents. The percent drug release in 30 min (Q30) and initial dissolution rate for formulation F3 was 98.61±0.25%, 3.29%/min. These were very much higher compared to marketed tablets (65.43±0.57%, 2.18%/min). The dissolution efficiency was found to be 63.37 and it is increased by 1.4 fold with F3 FDT tablets compared to marketed tablets. Differential scanning calorimetry and Fourier transform infrared spectroscopy studies revealed that there was no possibility of interactions. In conclusion, development of meclizine hydrochloride fast dissolving tablets by sublimation method is an appropriate method to enhance the dissolution rate.
