The present study has been achieved in three stages. The first stage involves the preparation of three acrylate monomer, the first one is 2, 2-dimethyl-1,3-dioxoylan-4-yl-methylacrylate (Solketal Acrylate) (SKA) and was prepared in two steps. The other two monomers act as functional and hydrophobic, 4- Acetylphenyl Acrylate (APA) and 4-formyl-2-methoxyphenylacrylate (VA) which prepared from vanillin; both prepared in a one-step reaction. All monomers were evaluated by 1H, 13C NMR and FTIR. In the next stage, two kinds of polymers have been fabricated. Free radical copolymerization of SKA with a different molar concentration of photo-cross-linker producing poly (SKA-co-DMIAAm), while the copolymerization between N-isopropylacrylamide with a different molar concentration of VA and APA for producing the thermo-responsive functional polymer. All polymers have been characterized chemically and physically. The lower critical solution temperature of thermo-responsive polymers was measured. Finally, the formation of gel thin films by deposition of photo-cross-linked polymer over gold thin film then cross-linked by UV irradiation was developed. The surface was chemically modified by the creation of hydroxyl groups. An additional layer of thermo-responsive functional polymer thin film was performed. The swelling of each layer was measured using surface plasmon resonance with an optical waveguide. The aim of the study is the formation of a gel multi-layer with a hydrophobic and hydrophilic character with a thermo-responsive upper layer and a non-responsive lower layer that facilitate the formation of gel vessel for targeting biomolecules.
Published Date: 2024-07-29; Received Date: 2020-06-09