Biochemistry & Molecular Biology Journal Open Access
ISSN: 2471-8084
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Abstract
RNA Polymerase II: Reading in Loops to get Different Tails
MA. Freire-Picos
The DNA-loops are necessary to recycle the RNA polymerase for the multiple transcription rounds of a gene. The nascent transcript needs to be 3’-end processed: cleaved in a specific position and added a 3´-end poly-(A)-tail to become an mRNA. Under regulated conditions, genes undergo 3´-end RNA processing at different positions. This is called alternative polyadenylation (APA) and, as a consequence, mRNA molecules could have different stabilities and regulated fates. The formation of alternative DNA loops is a key factor in order to get the APA.
