E.S.Bakhramov1, I.T.Nagieva2, N.I.Ali-zadeh1, T.M.Nagiev1,2
In recent years, nitrous oxide has been used as a selective oxidizing agent for the conversion of pyridine bases [1–2]. In this regard, we have experimentally studied oxidation of 2-picoline by nitrous oxide in the gas phase, without the use of catalysts, at atmospheric pressure.
For the first time, 2,2-ethylene dipyridine and 2,2-methylenedipyridine were obtained as a result of oxidation of 2-picoline by nitrous oxide. It was experimentally demonstrated that the yields of 2.2 ethylenedipyridine and 2,2-methylenedipyridine were as 30.3 wt.% and 1.5 wt.%, respectively. It was also shown that in the system of coherently synchronized free-radical reactions of nitrous oxide thermal decomposition and 2-picoline oxidation, the dimerization of 2-picoline mainly occurs.
Thus, the reaction of 2-picolinan oxidation by nitrous oxide demonstrates new development in heterocyclic synthesis, whereby 2,2-ethylene dipyridine was synthesized. The region where the reaction of coherently-synchronized oxidation of 2-picoline by nitrous oxide selectively occurs was identified and optimal conditions for obtaining the above products, necessary in the petrochemical, chemical, and pharmaceutical industries, were found.
