Studies on Inclusion Complex of 3-(2-Chloro Phenyl) 4-Methyl 2-Thiocarbamoyl-3, 3a Dihydro Pyrazolo[3,4c] Pyrazole

Sunakar P; a; Rabinarayana Sahu

Abstract

Studies on Inclusion Complex of 3-(2-Chloro Phenyl) 4-Methyl 2-Thiocarbamoyl-3, 3a Dihydro Pyrazolo[3,4c] Pyrazole

Sunakar Panda and Rabinarayana Sahu

The inclusion complex of 3-(2-chloro phenyl) 4-methyl 2- thiocarbamoyl-3,3a dihydropyrazolo[3,4c] pyrazole has been synthesized with β-cyclodextrin so as to improve its solubility and bio accessibility. The formation of inclusion complex has been ascertained by changes in melting point and spectral data (UV, IR, XRD, NMR etc). The determination of thermodynamic stability constant suggests that the inclusion complex has appreciable stability and its formation is thermodynamically allowed.The study of the antibacterial activity of the compound and its inclusion complex suggests that inclusion formation increases antibacterial activity significantly.