Letter to Editor - (2016) Volume 1, Issue 3
Department of Anesthesiology, Clinic Santiago de Leon, Caracas, Venezuela
Received date: June 06, 2016; Accepted date: June 15, 2016; Published date: June 21, 2016
Citation: Frederico C (2016) Can we Use the Cortinez's Model in Non-Obese Patients?. J child Obes 1:12. doi: 10.21767/2572-5394.100012
Copyright: © 2016 Frederico C. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Following the recent publication of our article in REDAR (Rev. Española de Anestesia y Reanimación) entitled “Comparison of the Cortínez and the Schnider models during effect-site TCI, at a target of 3 mcg/ml, in healthy volunteers." we want to emphasize that this is a clinical study, which demonstrates that Cortinez’s Model can be used in non-obese patients. The reasons for this are: the Cortinez’s data included normal-weight patients from Schnider`s study; the model included weight allometric adjustments for Volumes and Clearance. We decided to quantify the time of LOC and ROC, Bispectral Index, Blood Pressure, Heart Rate, Non-invasive Cardiac Output, and correlated with predicted concentration and mass of drug calculated by each Model in the same volunteer. The Non-invasive Cardiac Output is an easy interpreting tool, and it is directly related with the propofol’s pharmacokinetic in the first 5 minutes of the infusion. After analysing our data, the Cortínez’s model showed a better predictive ability at the moment of loss of consciousness than Schnider’s model [1]. Cortinez estimates a higher bolus induction compared to Schnider, due to its slower Ke0 (Tpeak 2.1 min-1), without generating significant changes in hemodynamics or the Cardiac Output during induction or maintenance of anaesthesia [2]. The methodology of our study is based on measurement of clinical parameters and the data obtained are relevant to anaesthesiologists in their daily practice.
Following the recent publication of our article in REDAR (Rev. Española de Anestesia y Reanimación) entitled “Comparison of the Cortínez and the Schnider models during effect-site TCI, at a target of 3 mcg/ml, in healthy volunteers." we want to emphasize that this is a clinical study, which demonstrates that Cortinez’s Model can be used in non-obese patients. The reasons for this are: the Cortinez’s data included normal-weight patients from Schnider`s study; the model included weight allometric adjustments for Volumes and Clearance.
We decided to quantify the time of LOC and ROC, Bispectral Index, Blood Pressure, Heart Rate, Non-invasive Cardiac Output, and correlated with predicted concentration and mass of drug calculated by each Model in the same volunteer. The Non-invasive Cardiac Output is an easy interpreting tool, and it is directly related with the propofol’s pharmacokinetic in the first 5 minutes of the infusion.
After analysing our data, the Cortínez’s model showed a better predictive ability at the moment of loss of consciousness than Schnider’s model [1]. Cortinez estimates a higher bolus induction compared to Schnider, due to its slower Ke0 (Tpeak 2.1 min-1), without generating significant changes in hemodynamics or the Cardiac Output during induction or maintenance of anaesthesia [2].
The methodology of our study is based on measurement of clinical parameters and the data obtained are relevant to anaesthesiologists in their daily practice.
