Journal of Childhood Obesity Open Access

There are clear associations between micronutrient deficiencies and obesity in various populations, and there is evidence to suggest that such deficiencies can affect leptin and insulin metabolism. However, there are multiple pathways by which a micronutrient deficiency could impair appetite regulation and energy metabolism, and these areas are poorly investigated in relation to human energy balance and obesity. Micronutrient deficiency in obesity may not be due to only inadequate intakes, but also due to changed metabolism and excretion. The complexity of the question is increased by the uncertainty as to how to assess and define the optimal status of vitamins, minerals and trace elements in obese individuals. However, at meiosis (the specialized nuclear divisions that happen during the assembly of gametes i.e., eggs and sperm), faulty pairing of an inverted or translocated chromosome set with a traditional set may result in gametes and hence progeny with duplications and deletions.