Insights in Biomedicine Open Access

In molecular biology, mutagenesis is an important laboratory technique whereby DNA mutations are deliberately engineered to produce libraries of mutant genes, proteins, strains of bacteria, or other genetically modified organisms. The various constituents of a gene, as well as its regulatory elements and its gene products, may be mutated so that the functioning of a genetic locus, process, or product can be examined in detail. The mutation may produce mutant proteins with interesting properties or enhanced or novel functions that may be of commercial use. Mutant strains may also be produced that have practical application or allow the molecular basis of a particular cell function to be investigated.

Insights in Biomedicine journal aimsto encourage interdisciplinary discussions and contributing to the advancement of medicine, benefiting readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly articles.

Mutations can have beneficial effects, deleterious effects, or no consequences in organisms. Certain mutations have a positive effect on the organism. The sickle cell mutation in the hemoglobin gene and hence the hemoglobin protein molecule, for instance, is thought to give humans in Africa an ability to survive malaria better. The resulting mutated hemoglobin aggregates in the red blood cells, leading them to assume a sickled shape, which makes it difficult for the malarial parasite to enter and infect the red blood cells. Many mutations are neutral and have no significant effect on the organism at all. However, certain types of mutations can have deleterious consequences in organisms.

All articles published by Insights in Biomedicine are made freely and permanently accessible online immediately upon publication, without subscription charges.

Peer-review is the system used to assess the quality of a manuscript before it is published. Researchers in the relevant research area assess submitted manuscripts for validity and significance to help editors determine whether the manuscript should be published in their journal.

All published articles of this journal are included in the indexing and abstracting coverage of Index Copernicus, Google Scholar, China National Knowledge Infrastructure (CNKI), Cosmos IF, Publons, Secret Search Engine Labs), Studies receiving funding from a funding organization that is included on the list of PMC and Research Funder Policies or authors having NIH grant were submitted to PubMed.

Benefits of publishing with Insights in Biomedicine journal are highvisibility,speed of publication after qualitative peerreview process. Open access policy allows maximum visibility of articles published in the journal as they are available to a wide, global audience.

Insights in Biomedicine articles are published under the terms of the Creative Commons Attribution License which permits use,distribution and reproduction in any medium,provided the original work is properly cited.

I would also like to express my gratitude to all the authors, reviewers, the publisher, the advisory and the editorial board of Insights in Biomedicine for their valuable support to bring out the Volume 6 of Insights in Biomedicine in scheduled time.