Perspective - (2022) Volume 8, Issue 6
Received: 01-Jun-2022, Manuscript No. IPJCE-22-13947; Editor assigned: 03-Jun-2022, Pre QC No. IPJCE-22-13947 (PQ); Reviewed: 17-Jun-2022, QC No. IPJCE-22-13947; Revised: 22-Jun-2022, Manuscript No. IPJCE-22-13947 (R); Published: 29-Jun-2022, DOI: 10.21767/2472-1158-22.8.28
Epigenetics is strongly influenced by the environment, including the diet, which is the source of metabolic substrates that affect the synthesis of chromatin and RNA modifying enzyme cofactors or substrates. In addition, plants are a common source of bioactive compounds that can directly alter the activity of these enzymes. Here we examine and discuss the effects of diet on epigenetic mechanisms such as chromatin and RNA regulation, and their potential effects on cancer prevention and treatment. The term “epigenetics” refers to a series of meiotic/ mitotic genetic changes in gene expression associated with environmental factors without disrupting the DNA sequence of the base. Recently, the pathophysiology of Autoimmune Diseases (AD) is closely associated with epigenetic modifications. Indeed, epigenetic mechanisms can regulate gene expression or suppression of target cells and tissues involved in autoimmune/ inflammatory conditions and act as key effectors in regulating adaptive and congenital responses.
Health systems around the world are facing serious challenges due to the increasing prevalence of Neuro Degenerative Diseases (NDDs). This mainly, but not exclusively, affects the ever-growing elderly population. The most well-known neurodegenerative diseases are Alzheimer’s disease (AD) and Parkinson’s disease, multiple sclerosis, and muscular atrophic lateral sclerosis, but viral infections of the brain and traumatic brain injury can also cause NDD. NDD is characterized by neuronal dysfunction and its irreversible loss, often leading to irreversible dementia and ultimate death. Many factors are involved in the pathogenesis of NDD, including genetic diversity, metastatic changes, and levels of oxidative/nitrosation stress, mitochondrial dysfunction, and DNA damage. The complex interaction of all the above factors can be a fingerprint of neurodegenerative disease, and different diseases are affected to varying degrees by specific factors. Primary Aldosteronism (PA) is the most common cause of endocrine hypertension, primarily caused by aldosterone-producing adenomas or hyperplasia. Understanding their pathophysiological background is important for developing better treatment strategies. Significant advances in this area have been documented in recent years, especially in the elucidation of the genetic and molecular mechanisms responsible for the etiology of Aldosterone Producing Adenomas (APA). Extensive exposure to maternal metabolism and endocrine status, nutrition, stress, toxins, etc. can affect the placenta. Epigenetic changes in the placenta induced by these exposures may mediate sustained effects on placental function. Identifying exposures that have the greatest impact on placental function and offspring health is the key to focusing on future research and developing stratified, individualized interventions. For example, the parental environment affects the imprinting pattern of gamete cells and ultimately the gene expression of the embryo. This leads to hypersensitivity of pregnant mothers to malnutrition and increases the risk of cognitive impairment in later years.
Alcohol-Related Liver Disease (ARLD) is the leading cause of chronic liver disease in the United States. Despite advances in diagnosis and treatment of ARLD, it is a major public health problem associated with significant morbidity and mortality, emphasizing the need for new approaches to study ARLD and its complications. increase. Epigenetic changes are increasingly recognized as contributing to the etiology of several medical conditions.
Citation: Mcewan I (2022) Epigenetic Nutrition in DNA and RNA. J Clin Epigen. 8:28.
Copyright: © Mcewan I. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
