Short Communication - (2024) Volume 5, Issue 2
Received: 29-May-2024, Manuscript No. JAC-24-20931; Editor assigned: 31-May-2024, Pre QC No. JAC-24-20931 (PQ); Reviewed: 14-Jun-2024, QC No. JAC-24-20931; Revised: 19-Jun-2024, Manuscript No. JAC-24-20931 (R); Published: 26-Jun-2024, DOI: 10.35841/jac.5.2.12
Kinins are a group of bioactive peptides that play significant roles in inflammation, blood pressure regulation, pain, and cardiovascular health. The primary kinins, bradykinin and kallidin, are generated from kininogen precursors through the action of kallikrein enzymes. Bradykinin, the most well-studied kinin, is a potent vasodilator, contributing to the regulation of blood pressure by promoting the dilation of blood vessels. It also increases vascular permeability, allowing immune cells to access sites of injury or infection, thereby facilitating the inflammatory response. Additionally, kinins interact with specific receptors, such as B1 and B2 receptors, to mediate pain signals, making them integral to nociception, or the perception of pain. Despite their beneficial roles, excessive kinin activity can lead to pathological conditions, such as hereditary angioedema, characterized by severe swelling and inflammation. Therapeutic strategies targeting kinin signaling, such as kinin receptor antagonists and kallikrein inhibitors, show promise in treating these conditions. Understanding kinins’ complex roles in health and disease is critical for developing effective therapies that leverage their physiological benefits while mitigating pathological effects, offering potential solutions for managing inflammatory and cardiovascular disorders. Therapeutically, kinin receptor antagonists and kallikrein inhibitors are being explored for their potential to treat inflammatory and cardiovascular diseases. The complex interplay between kinins, their receptors, and the enzymes that regulate their production underscores their importance in maintaining physiological balance and responding to pathological conditions [1,2].
Kinins are a family of bioactive peptides that include bradykinin and kallidin, which are generated from kininogen precursors by kallikrein enzymes. These peptides play vital roles in inflammation, blood pressure regulation, pain, and cardiovascular health. Bradykinin, the most well-known kinin, acts on B1 and B2 receptors to induce vasodilation, increasing blood flow and lowering blood pressure. It also enhances vascular permeability, facilitating the movement of immune cells to sites of injury or infection, thus promoting inflammation and tissue repair. Additionally, kinins are involved in pain modulation by stimulating sensory nerves, leading to the perception of pain. Despite their beneficial roles, excessive kinin activity can contribute to conditions such as hereditary angioedema, characterized by severe swelling and inflammation. Kinins also play a role in cardiovascular diseases, with dysregulated kinin signaling linked to hypertension and heart failure. Therapeutic approaches targeting the kinin system include the use of kinin receptor antagonists and kallikrein inhibitors to treat inflammatory and cardiovascular disorders. Understanding the complex roles of kinins in health and disease is essential for developing effective therapies that leverage their physiological benefits while mitigating pathological effects [3,4].
Kinins, including bradykinin and kallidin, play essential roles in inflammation, blood pressure regulation, pain, and cardiovascular health. By inducing vasodilation and increasing vascular permeability, they facilitate immune cell movement and tissue repair. However, excessive kinin activity can lead to conditions like hereditary angioedema and contribute to cardiovascular diseases. Therapeutic strategies targeting kinin signaling, such as kinin receptor antagonists and kallikrein inhibitors, show promise in treating these conditions. Understanding kinins’ complex roles in health and disease is critical for developing effective therapies that leverage their physiological benefits while mitigating pathological effects, offering potential solutions for managing inflammatory and cardiovascular disorders.
None.
The author’s declared that they have no conflict of interest.
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Citation: Hanway J (2024) Kinins and Inflammation: Regulatory Peptides in Vascular Tone and Immune Response. Autacoids J. 5:12.
Copyright: © 2024 Hanway J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.