Journal of Clinical Gastroenterology and Hepatology Open Access

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Image - (2017) Volume 1, Issue 2

Renal Cell Carcinoma with Gastric and Paratracheal Metastases

Rodrigues AN*, Pranavan G and Gananadha S

Department of General Surgery, The Canberra Hospital, 77 Yamba Drive, Garran, Australia

*Corresponding Author:

Rodrigues AN
Department of General Surgery
The Canberra Hospital, 77 Yamba Drive
Garran, ACT 2605, Australia
Tel: +61402902282
E-mail: Nicole.rodrigues@act.gov.au

Received date: May 05, 2017; Accepted date: May 06, 2017; Published date: May 08, 2017

Citation: Rodrigues AN, Pranavan G, Gananadha S. Renal Cell Carcinoma with Gastric and Paratracheal Metastases. J Clin Gastroenterol Hepatol 2017, 1:2. doi: 10.21767/2575-7733.10000i15

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Abstract

Renal cell carcinoma (RCC) has been known metastasize to almost all organ systems [1], however gastric metastasis is rare, with 50 cases reported in the literature to date [2]. There are also few reports of Para-tracheal RCC metastases. Here we describe a case of a 73-year-old patient with disseminated metastatic renal cell carcinoma (RCC) with gastric metastasis and a large para-treacheal deposit resulting in tracheal invasion and compression.

Description

Renal cell carcinoma (RCC) has been known metastasize to almost all organ systems [1], however gastric metastasis is rare, with 50 cases reported in the literature to date [2]. There are also few reports of Para-tracheal RCC metastases. Here we describe a case of a 73-year-old patient with disseminated metastatic renal cell carcinoma (RCC) with gastric metastasis and a large para-treacheal deposit resulting in tracheal invasion and compression.

The RCC was initially resected in 2009 with a right partial nephrectomy, followed by a complete right nephrectomy in 2014 after tumour recurrence. He had stable disease on Pazopanib, however presented in August 2016 with melena, and was found to have a large polypoid lesion at the gastric greater curvature on gastroscopy (Figure 1). This was revealed to be an ulcerated metastatic RCC deposit on histopathology. He underwent a distal gastrectomy in September 2016 and was commenced on Sunitinib. PET-CT also showed a suspicious large left para-tracheal mass (Figures 2 and 3), and despite the chemotherapy, had grown on a subsequent CT in January 2017, with tracheal deviation and invasion causing haemoptysis and stridor. After multidisciplinary consultation, he decided for palliative treatment and died due to acute respiratory distress 5 days later.

clinical-gastroenterology-hepatology-Gastric-RCC-deposit-gastroscopy

Figure 1:Gastric RCC deposit on gastroscopy in August 2016.

clinical-gastroenterology-hepatology-left-paratracheal-deposit-causing

Figure 2:CT axial slice of left paratracheal deposit causing tracheal deviation in January 2017.

clinical-gastroenterology-hepatology-FDG-avid-gastric-lesion

Figure 3:PET/CT of left paratracheal deposit, again demonstrating tracheal deviation to the right, as well as the FDG avid gastric lesion.

References

  1. Maldazys JD, DeKernion JB (1986) Prognostic factors in metastatic renal carcinoma. Journal of Urology136:376-379.
  2. Akay E, Kala M, Karaman H (2016) Gastric metastasis of renal cell carcinoma 20 years after radical nephrectomy. Turk J Urol 42:104-107.