2HUN-REN–PTE Human Reproduction Research Group, 7624, 17 Edesanyak Str., Pecs, Hungary
Research Article
Detection of Ultra-Weak Photon Emissions from Mouse Embryos with Implications for Assisted Reproduction
Author(s): Jozsef Bodis, Bernadett Nagy*, Zoltan Bognar, Timea Csabai, Jozsef Berke, Istvan Gulyas, Peter Mauchart, H. R Tinneberg, Balint Farkas, Akos Varnagy and Kalman Kovács
Background: In the past four decades, In Vitro Fertilization (IVF) has benefited from substantial
advancements and become a routine medical procedure. Embryo development can be moderated
with time lapse systems, but such systems use visible light that can harm cells. Living cells have
spontaneous Ultraweak Photon Emissions (UPEs) that are generated by metabolic reactions and
influenced by physiological conditions.
Methods: Embryo-emitted photons were detected with a custom in-house ORCA-Quest CMOS camera
and microscope incubator system. Images were taken in the dark. Negative control measures were
taken for an empty vessel and a vessel with only oil and media. Optimal data were collected with all
software filters off.
Findings: Reference measurements showed only negligible differences betw.. View More»
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