Journal of Clinical Epigenetics Open Access

Rajesh Singh Yadav

Biography

Dr. Rajesh Singh Yadav has received his PhD in Toxicology from Jamia Hamdard New Delhi, India and CSIR-Indian Institute of Toxicology Research, Lucknow , India in the year 2012. He is presently working as Assistant Professor at Department of Criminology and Forensic Science in Dr. Harisingh Gour Central University, Sagar, India. His research has included the effect of environmental toxicants on the neurobehavioral toxicity of individuals. Based on this research and fellowship training he has received several awards and honors, such as Jyotsnamoyee - Raghunath Bhattacharya Young Scientist Prize for the best published paper by the Indian Academy of Neurosciences in 2009 and also received University of Minnesota Research Excellence Award for presenting his work at the Annual Meeting of Society of Toxicology, India in 2010. Besides, he is the recipients of Travel Awards for excellent presentation at Neuroscience 2011 organized by the Japan Neuroscience Society at Yokohama, Japan. He has also been awarded Best Student Poster Presentation Award at the joint meeting of APSN and JSN at Kobe, Japan in 2012. He is also recipients of ISN-APSN-IBRO Travel Fellowship, Professor R. Nath Memorial Travel Award and Melvin Yahr Travel Award to present his work at various scientific platforms. He has published various research papers and 02 books and has two projects running

Research Interest

The research work was focused on to investigate the neuroprotective efficacy of curcumin and Bacopa monnieri, a cognitive enhancer against neurobehavioral toxicity of arsenic, a environmental contaminant and monocrotophos, an organophosphate pesticide respectively in rats. The study involves behavioural, neurochemical and molecular techniques exhibited that arsenic induced learning and memory deficits linked with brain cholinergic dysfunctions and motor impairment linked with brain dopaminergic alterations in rats were protected following simultaneous treatment with curcumin. It was further demonstrated that protective changes of curcumin were due to its anti-oxidant potential and metal binding property as arsenic induced oxidative stress and reduced the load of arsenic in the brain regions. In another set of study, monocrotophos induced decrease in the activity of AChE and binding of muscarinic-cholinergic receptors linked with learning and memory deficits, grip strength was found to be protected in rats simultaneously treated with B. monnieri. Interestingly, alterations in DA-D2 receptors associated with impaired motor activity, rotarod performance, 5-HT2A receptors and enhanced oxidative stress in the brain were found to be protected in rats simultaneously treated with B. monnieri. The study demonstrated that neurotoxic alterations due to environmental contaminants could be protected following simultaneous treatment with herbal or pharmacological agents.