Insights in Analytical Electrochemistry Open Access

Determination of 27 phenolic compounds in human urine by LC-MS/MS with online SPE system

Joint Event:8^th Annual Congress on Analytical and Bioanalytical Techniques & 14^th International Conference and Exhibition on Pharmaceutical Formulations

August 28-30, 2017 Brussels, Belgium

Yoon Jae Cho, In Kyung Bae, Dahyun Jeong, Min Jeong Jo, Seul Gi Lee, Myungsil Hwang and Yong Eui Koo

National Institute of Food and Drug Safety Evaluation, South Korea

Posters & Accepted Abstracts: Insights Anal Electrochem

Abstract:

Several phenolic compounds exposed to us in daily life are toxic. Xenobiotic substances are classified as endocrine disruptors with negative effect on the hormonal system. To assess the content of exposure to these chemicals in human, the accurate and efficient monitoring of extent of contaminants is desirable. This study describes a simple and sensitive analytical method for 27 phenolic compounds and their metabolites including bisphenol-F and bisphenol�S using high-performance liquid chromatography tandem mass spectrometry coupled with online solid phase extraction (online SPE) system. Particularly, bisphenol-F and bisphenol�S are alternatives to bisphenol-A as a raw material of plastic. This study will show the simplicity and validation result of this method which is being able to efficiently analyze a large number of human urine samples to assess the human exposure to phenolic compounds.

Biography :

Yoon Jae Cho completed PhD from Pusan National University, Korea. He is the Scientific Officer of Ministry of Food and Drug Safety, Korea. He has been working in the field of development of analytical method for veterinary drug residues in livestock and fishery products using LC-MS/MS for the past five years, and he is currently involved in field of human biomonitoring for hazard assessment of harmful substances.