Dara Kutsyk and Elena Sklyarova
Danylo Halytsky Lviv National Medical University, Ukraine
Posters & Accepted Abstracts: J Diabetes Res Endocrinol
Introduction: Diabetic nephropathy (DN) is the main reason of end stage renal disease (ESRD) in the whole world. Data of different investigations suggest that oxidative stress plays role in pathogenesis of type 2 diabetes (T2D) and its complications. Hydrogen sulfide (H2S) is the third member of family of gasotrasmitters (the first two are nitric oxide (NO) and carbon monoxide (CO)). They take part in such processes as oxidative stress, inflammation and hypoxia. In some studies is shown that indication of H2S donors improves kidney recovery after is?hemic injury. Thatâ??s why we try to check if lack of H2S can lead to DN. Matherial & Methods: The investigation included 60 patients with T2D (30 men and 30 women) who undergo treatment in Lviv Emergency Hospital. Mean age of all patients was 57.0?±9.8 years. Except standard physical and laboratory examination, additional sample of blood for H2S was taken and 24 hours of urine sample for microalbuminuria (MAU) was collected. Control group consists of 15 absolute healthy subjects. The diagnosis of T2D and DN was made due to IDF criteria (2015). All patients were divided in two groups: patients without DN and with DN. Results: H2S level in control group (54.25?±1.5 ?µmol) was significantly lower than in patients with T2D (64.2?±8.2 ?µmol; p<0,001). But H2S level in the first group (69.2 ?± 6.4 ?µmol) was higher than in the second group (62.9?±8.2 mol; p<0,05). We also revealed moderate negative correlation between MAU and H2S ( r=-0.47957). Conclusions: Decrease of H2S can lead to MAU and development of DN.
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