Journal of Infectious Diseases and Treatment Open Access

Interleukin-36 expression in vitiligo skin lesions and its correlation with disease pattern, activity and severity

Joint Event on 10^th Euro-Global Conference on Infectious Diseases & 5^th International Conference on Histopathology & Cytopathology

September 27-29, 2018 Rome, Italy

Sahar F Mansour, Mona A Atwa, Lina M Atef and Rasha Mohamed Ibrahim Mohamed

Suez Canal University, Egypt Ismailia General Hospital, Egypt

Posters & Accepted Abstracts: J Infec Dis Treat

Abstract:

Vitiligo is an acquired multivariate disease, that results in gradual selective degeneration of cells that produce pigmentation in the skin. There is still an ongoing debate about what causes damage to melanin cells and their disappearance from infected skin. Many theories to explain the pathogenesis of vitiligo exist. Recently, one of the autoimmune pathogens theory has been suggested. Interleukin (IL)-36α belongs to interleukin (IL)36-cytokine family, that have a role in organizing non specific as well as acquired immune responses. It is proved that interleukin 36 in many skin disorders, especially autoimmune ones including for example psoriasis. The study will be conducted in an attempt to evaluate interleukin 36α expression using IHC in skin (lesional and non lesional) punch biopsy from vitiligo patients and detect the correlation between interleukin 36α expression with demographic (age, gender,..) and clinical parameters (disease pattern, activity and severity).

Biography :

Sahar F Mansour has completed her MD from Suez Canal University, Ismailia, Egypt. She is an Assistant Professor of the Pathology Department of Faculty of Medicine, a premier research organization. She has published more than 10 papers in reputed journals.

E-mail: sfansour36@gmail.com