Journal of Infectious Diseases and Treatment Open Access

Preoperative nasopharyngeal decolonization using mupirocin and chlorhexidine in preventing surgical site infection: A meta-analysis

Joint Event on 10^th Euro-Global Conference on Infectious Diseases & 5^th International Conference on Histopathology & Cytopathology

September 27-29, 2018 Rome, Italy

Buaron Michelle Jane A, Semeniano Russel, Ombao Genevie and Y U Catherine

St. Lukes Medical Center, Philippines

Posters & Accepted Abstracts: J Infec Dis Treat

Abstract:

Background: Preoperative decolonization is a preventive strategy for surgical site infection. Clinical trials have been done to prove or disprove the efficacy of decolonization in the prevention of surgical site infection. However, great heterogeneity in results was noted in many published studies. Objective: We assessed whether preoperative decolonization reduces the risk of surgical site infection. Method: PubMed and Google free texts search terms: decolonization and surgical site infection inclusion criteria: >/=18 years old of either gender undergoing any surgery, may or may not screened for carriage of S. aureus; studies are randomized controlled trial (RCT). Results: Using the random effects model, the computed summary statistic was 0.59 with CI 0.37-0.94 in favor of the experimental treatment. However, due to substantial heterogeneity (Tau2 of 0.25 Chi2 30.34 and I2 of 84%), we cannot draw definite conclusion from the meta-analysis. Subgroup analysis using both mupirocin nasal swab and chlorhexidine gargle were used for preoperative decolonization, the summary statistic generated was 0.40 with 95% CI of 0.23-0.69, with no heterogeneity (Tau2 of 0, Chi2 of 0.09 and I2 of 0.) and was noted to be in favor of the experimental treatment. Conclusion: Pre-operative decolonization using both mupirocin and chlorhexidine for preoperative decolonization showed that it could significantly prevent surgical site infection.

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