Denis Prat
Sanofi Aventis, France
Posters & Accepted Abstracts: Trends in Green chem
As solvents represent most of the material used to produce an Active Pharmaceutical Ingredient, selecting the "greenest" solvents and reducing their amount is the most effective way to improve the sustainability of its synthesis. Several solvent selection guides have been published by pharmaceutical companies or institutions (Pfizer, GSK, GCI-PR, and Sanofi). A special focus on Sanofi�s guide will be made. As part of the European project CHEM21, a survey of these solvent guides has been made, permitting to rank many classical solvents into four categories, from "recommended" to "highly hazardous". In order to rank less classical solvents, and in particular bio-derived solvents, a methodology has been developed. A set of Safety, Health and Environment scores is proposed, based on very easily available physical properties and GHS statements. A simple combination of these scores gives a preliminary ranking of any solvent. The CHEM21 solvent selection guide thus obtained is the first guide integrating bio-derived solvents. The guide and the methodology have been integrated in the CHEM21 on-line training platform, which is publically available. A demonstration of this platform will be made.
Email: denis.prat@sanofi.com
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