Insights in Analytical Electrochemistry Open Access

Spherical crystals of celecoxib to improve solubility, dissolution rate and micromeritic properties

Joint Event:8^th Annual Congress on Analytical and Bioanalytical Techniques & 14^th International Conference and Exhibition on Pharmaceutical Formulations

August 28-30, 2017 Brussels, Belgium

Venkadari Rammohan Gupta

Pulla Reddy Institute of Pharmacy, India

Posters & Accepted Abstracts: Insights Anal Electrochem

Abstract:

Celecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone, water and chloroform as solvent, non-solvent and bridging liquid, respectively. The agglomerates were characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), IR spectroscopic studies and scanning electron microscopy (SEM). The IR spectroscopy and DSC results indicated the absence of any interactions between drug and additives. XRD studies showed a decrease in crystallinity in agglomerates. The crystals exhibited significantly improved micromeritic properties compared to pure drug. The loading efficiency (% or mg drug per 100 mg crystals) was in the range of 93.9�±2.3 and 97.3�±1.3% (n=3) with all formulations. The aqueous solubility and dissolution rate of the drug from crystals was significantly (p<0.05) increased (nearly two times). The solubility and in vitro drug release rates increased with an increase in PVP concentration (from 2.5 to 10%). The SEM studies showed that the crystal possesses a good spherical shape with smooth and regular surface.