Polymer Sciences Open Access

Structure/property correlations in anticancer drug loaded polycaprolactone nanoparticles prepared via double emulsion technique

4^th Edition of International Conference and Exhibition on Polymer Chemistry

March 28-29, 2019 Rome, Italy

Tatiana E Sukhanova, Milana E Vylegzhanina, Anatoly Y Volkov, Alexandr A Kutin, Svetlana V Valueva, Ekaterina R Gasilova, Amal Amin, Moshera Samy, Heba M Abdallah and Magdy M H Ayoub

Institute of Macromolecular Compounds-RAS, Russia S V Lebedev Institute of Synthetic Rubber, Russia National Research Center, Egypt

Posters & Accepted Abstracts: Polym Sci

Abstract:

In this study, biodegradable polymer polycaprolactone nanoparticles (PCNs) were prepared by a modified Water/Oil/Water (W/O/W) double emulsion-solvent diffusion method using dichloromethane as solvent and polyvinyl alcohol (PVA) as stabilizer. 5-Fluorouracil (5-FU), the anticancer drug, was used for loading into PCNs. Structure, morphology, particles size distribution, optical and thermal properties of drug loaded 5-FU-PCNs were evaluated by different characterization techniques such as X-ray diffraction (XRD), atomic-force microscopy (AFM), optical and transmission electron microscopy (OM and TEM), dynamic light scattering (DLS) and differential scanning calorimetry (DSC) methods. XRD and DSC analysis indicated a molecular level dispersion of drug in the polymer matrix. AFM and TEM data confirmed complicate morphology and spherical shape of the 5-FUPCNs prepared. The optimized ratios of the different parameters of double emulsion process were founded. Correlations between structural and morphological parameters, preparation conditions (concentration of stabilizer, etc.) and drug encapsulation efficiency (EE%)/ drug release from these nanoparticles were evaluated. It can be concluded that the prepared PCNs can be effectively used for preparation of controlled release matrices for anticancer drugs.

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