Trends in Green Chemistry Open Access

Ultrasound and microwaves assisted synthesis of molecules with antiquorum sensing activity

Joint Event: 5^th International Conference on Green Chemistry and Technology & 6^th International Conference on Environmental Chemistry and Engineering

July 24-26, 2017 Rome, Italy

Alicia Reyes-Arellano, Jenifer Torres-Jaramillo and Delfino J Vera-Mercado

National Polytechnic Institute, Mexico

Scientific Tracks Abstracts: Trends in Green chem

Abstract:

Statement of the Problem: It is necessary to synthesize molecules that can function as biososteres1 of acyl homoserine lactones2 (AHL) or biois�³steres of tirosol,3 which can be evaluated on Gram-negative bacteria or Candida albicans respectively. On the other hand it is indispensable that the synthesis is carried out considering energy efficiency, operational simplicity and good yield in short times. By the above mentioned, molecules were designed for this purpose and planted some chemical synthesis procedures. Findings: Compounds 1 were synthesized in two steps, from p-hidroxy benzaldehyde,4 one of them was carried out by sonication. Compounds 2 were totally synthesized by sonication, based on a report of literature5; global isolated yield 85-95%. Synthesis of compounds 3 and 4 involves a cyclization, it was carried out by MW or ultrasound. Good yields were obtained when the raw material contain long chains. Excellent yields were achieved when the raw material had short chains. The ultrasound has the advantage the time is minimum compared with MW or conventional heating. Compounds 3 were prepared from p-amino toluene and compound 4 from p-hydroxibenzaldehyde. It is important to mention that alkylation of p-hydroxibenzaldehyde demands 18h of heating, while using MW the reaction requires only 4h and 2h with ultrasound. Conclusion & Significance: Diols, alcohols and imidazolines were prepared using a very simple protocols using MW or ultrasound in good to excellent yields. The synthesized compounds are currently evaluated as antiquorum sensing molecules in Serratia marcescens and Candida albicans, in fact some of them present activity as antiquorum sensing compounds.

Biography :

Alicia Reyes-Arellano has her expertise in design and synthesize of compounds with pharmacological activity and passion in improving the synthetic procedures according the green chemistry. Her fields are organic chemistry, medicinal chemistry and nanostructures synthesis. She has interest in teaching and improved the plans and curricula in her Institution. She is also interested on HPLC-MS studies.

Email: areyesarellano@yahoo.com mx a_reyesa@hotmail.com