This therapy contains three or more retroviral drugs to stop the progression of HIV disease. These drugs are separated into different classes. The classes are nucleoside /nucleotide reverse transcript inhibitors, non-nucleoside reverse transcript inhibitors, protease inhibitors, fusion inhibitors, integrase inhibitors, fixed dose combinations. These drugs prevent the growth of virus. This therapy very useful in HIV starting stages. This therapy is mainly for prevention of HIV in pregnant women and young children’s.