Biotechnology is the use of living systems and organisms to develop or make products, or "any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use", integration of natural science and organisms, cells, molecular analogues for products and services a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Depending on the tools and applications, it often overlaps with the related fields of bioengineering, biomedical engineering, bio manufacturing, molecular engineering, etc.