Cystic fibrosis (CF) is an autosomal recessive genetic disorder that affects the lungs, pancreas, liver, and intestine. Its main characteristic is disrupted transport of chloride and sodium across an epithelium, which leads to thick, viscous secretions. It is also known as mucoviscidosis. Abnormal breathing is the most serious symptom which results from frequent lung infections. Cystic fibrosis is caused by a frameshift mutation in the gene for the protein cystic fibrosis transmembrane conductance regulator (CFTR). The name cystic fibrosis was given because there is a cyst formation in the Pancreas. The thick mucus secretion occurring due to cystic fibrosis block the way of digestive and endocrine enzymes of pancreas, causing a complete damage to pancreas.
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