Retrovirus belongs to Retroviridae family, Retro virus contains two copies of RNA genome, Retrovirus integrated there into own genome into the germ line.it transmitted through cell to cell or fluids.it integrates the genetic material with the hosts, the virus becomes the part of the hosts genome for life. Retrovirus causes variety diseases in humans and animals, Such as tumours. Antiretroviral drugs are used for the treatment of retrovirus it’s also called as Highly Active Antiretroviral Therapy.