MDD called as “Major depressive disorder," and called with different names as clinical depression, major depression, unipolar depression, or unipolar disorder. It is a serious clinical mood disorder in which frustration, loss, or anger interferes with a person′s everyday life, feelings of sadness. Symptoms include irritability, difficulty with concentration, feelings of hopelessness, feelings of worthlessness, guilt, or self-hate, social isolation, and loss of interest, sleep problems (insomnia or excessive sleeping).