Christine Florens, Nur Aisiyah Widjaja* and Roedi Irawan
Objective: Adiponectin plays an essential role in the relationship between obesity and insulin resistance. This study aimed to analyze whether serum adiponectin levels are associated with adiponectin gene rs2241766 polymorphism and dietary patterns.
Methods: This cross-sectional study involved Javanese adolescents aged 13-18 years with obesity. Obesity was defined according to the centers for diseases control and prevention 2000 criteria. Blood samples were collected to determine serum adiponectin levels through enzyme-linked immunosorbent assay and adiponectin gene rs2241766 polymorphism through polymerase chain reaction restriction fragment length polymorphism. Dietary patterns were described using energy consumption percentages from carbohydrates and fat, calculated from a 24-hour dietary recall for 2 consecutive days.
Results: We included 240 adolescents with obesity. Genotype distributions of the adiponectin gene rs2241766 polymorphism were 61.3%, 34.6% and 4.2% for the TT homozygous, TG heterozygous and GG homozygous variants, respectively. The median serum adiponectin level was 13.9 (1.5-46.6) μg/mL.
Conclusion: Serum adiponectin levels were not significantly associated with higher fat or carbohydrate consumption and adiponectin gene rs2241766 polymorphism.
Published Date: 2023-12-28; Received Date: 2023-06-19
