Currently, the use of plant based natural gums and mucilage are increased in manufacturing of pharmaceutical dosage forms as retarding polymers and excipients, because these natural plant based materials are biocompatible, biodegradable, free of side effects and economic. Therefore in the present research work, eight different formulations of vildagliptin matrix tablets were formulated with Hibisus leaves mucilage, zein powder and tamarind seed polysaccharide as natural polymers to sustain and extend the vildagliptin release from the matrix system and wet granulation technique used for preparation of matrix tablets. The prepared matrix tablets were evaluated for pre-compression and post-compression parameters. Hence the developed matrix tablets of all the formulations passed all the standard evaluation tests (pre-compression and post-compression parameters) and the difference between both the polymers in terms of drug release was examined. V1 formulation extended the release unto 24 hrs, considered as best formulation. The dissolution data of all formulations fitted into kinetic models like zero order equation, first order equation, Hixson Crowell equation, Higuchi equation and Korsemeyer-peppas equation in order to determine the order of drug release and mechanism. The release kinetics of best formulations showed zero order release and followed Higuchi mechanism.
Published Date: 2023-03-14; Received Date: 2023-02-07
