Department of Pharmacy, Sri Ramachandra University, Chennai, India
Research Article
Design and Evaluation of Vildagliptin Matrix Tablets by Response Surface Methodology
Author(s): Deepika B* and Sujatha K
Currently, the use of plant based natural gums and mucilage are increased in manufacturing of pharmaceutical dosage forms as retarding polymers and excipients, because these natural plant based materials are biocompatible, biodegradable, free of side effects and economic. Therefore in the present research work, eight different formulations of vildagliptin matrix tablets were formulated with Hibisus leaves mucilage, zein powder and tamarind seed polysaccharide as natural polymers to sustain and extend the vildagliptin release from the matrix system and wet granulation technique used for preparation of matrix tablets. The prepared matrix tablets were evaluated for pre-compression and post-compression parameters. Hence the developed matrix tablets of all the formulations passed all the standard evaluation tests (pre-compression and post-compression parameters) and the difference.. View More»
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