Rogelio Zayas Borquez*, Alfonso Fernandez Ramirez, Oscar Santes Jasso, Emmanuel Posadas Trujillo and Yoselin Julisa Sarabia Perez
Introduction: Neutropenic Enterocolitis (NE) is a severe complication in immunosuppressed patients, especiallythose undergoing intensive oncological treatments. Predicting mortality in these patients is crucial for optimizing clinical management and improving therapeutic outcomes.
Methods: We conducted a systematic review of 24 clinical studies, including 1,172 patients diagnosed with neutropenic enterocolitis. Data sources included PubMed and Google Scholar, with the last search performed on September 13, 2024. Studies were selected based on inclusion criteria, such as adult patients, availability of mortality data, and the use of G-CSF, while exclusion criteria included pediatric populations and case reports. Clinical variables analyzed included ICU admission, surgical management, comorbidities, severity of neutropenia, and diagnostic timing.
Results: A total of 14.40% of patients required ICU admission, and 43% needed surgical management. Mortality was 23.60%, and the use of G-CSF significantly reduced mortality (10.75% vs 44.44%, p<0.001). Late diagnosis was associated with higher mortality (48.28% vs 15.56%, p<0.01). A predictive scale based on these risk factors stratified mortality risk into low, moderate, and high categories.
Conclusion: The proposed scale shows potential for identifying patients at high mortality risk, allowing for more personalized interventions. External validation is needed to confirm its effectiveness.
Published Date: 2024-10-22; Received Date: 2024-09-24
