Byung Soo Yoo*, Benjamin L. Robinson, Ana Vilela, Alsiddig Elmahdi, Kevin Houston and David A. Johnson
Highlighting the expanding research on the Gastrointestinal (GI) microbiome, this review explores its pivotal role in disease pathogenesis, specifically, gastroesophageal reflux disease, barrett’s esophagus, eosinophilic esophagitis, inflammatory bowel disease, colon cancer and hepatobiliary disease. The immune system acts as a crucial bridge, connecting the gut microbiome to these GI disorders. Studies demonstrate that microbial dysbiosis triggers immune responses, initiating a pro-inflammatory cytokine cascade. This reciprocal inflammatory interplay between the host’s immune system and GI microbiome contributes to disease progression, emphasizing significant potential for diagnostic and therapeutic implications.
Published Date: 2024-09-04; Received Date: 2024-07-31
