Department of Gastroenterology and Medicine, Advocate Health Wake Forest, Charlotte, North Carolina, United States of America
Review Article
Gut Microbiome and Immune Responses in Gastrointestinal Diseases
Author(s): Byung Soo Yoo*, Benjamin L. Robinson, Ana Vilela, Alsiddig Elmahdi, Kevin Houston and David A. Johnson
Highlighting the expanding research on the Gastrointestinal (GI) microbiome, this review explores its
pivotal role in disease pathogenesis, specifically, gastroesophageal reflux disease, barrett’s esophagus,
eosinophilic esophagitis, inflammatory bowel disease, colon cancer and hepatobiliary disease. The
immune system acts as a crucial bridge, connecting the gut microbiome to these GI disorders. Studies
demonstrate that microbial dysbiosis triggers immune responses, initiating a pro-inflammatory
cytokine cascade. This reciprocal inflammatory interplay between the host’s immune system and GI
microbiome contributes to disease progression, emphasizing significant potential for diagnostic and
therapeutic implications... View More»
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