Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan
Research Article
Role of Interleukin 17-A Rs2275913 Polymorphism in Susceptibility to Autoimmune Diseases: A Meta-Analysis
Author(s): Abdulkadir Yusif Maigoro* and Syeda Hafiza Benish Ali
Interleukin 17-A (IL17A) is one of the major cytokines known to play a role in different pathologies, including Autoim- mune Diseases (AIDs). IL17A gene has different Single Nucleotide Polymorphisms (SNPs); rs2275913 being frequent- ly studied SNP with susceptibility to autoimmune diseases. However, the results for this SNP have remained incon- clusive. Therefore, in this meta-analysis we gathered data from different studies conducted in different populations (Europe, Asia, New Zealand, Africa and Latin America) to find out the role of rs2275913 in overall susceptibility of AIDs. After thorough search and careful screening, a total of 5424 cases and 7221 controls were cumulatively found in 16 eligible studies from 13 different research papers. Analyses were done under co-dominant homozygous (AA vs. GG), co-dominant heterozygous (GA vs. GG), dominant (AA+GA.. View More»
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 