Department of Biochemical Engineering, Indian Institute of Technology, Varanasi, Uttar Pradesh, India
Research Article
Biogenic Synthesis of Cadmium Sulfide Nanoparticles Using Daruharidra (Berberis aristata) and Its Implementation as a Novel Therapeutic Agent against Human Breast and Ovarian Cancer
Author(s): Aditi Bhatnagar and Abha Mishra*
In this article we have illustrated a novel biogenic and green approach for the production of CdS
Nanoparticles (CdS NPs) within 3 nm-5 nm range using an excellent ayurvedic herb known as
Daruharidra (Berberis aristata). Natural and chemical free daruharidra powder was utilized as a
stabilizing agent in the green or biogenic synthesis of CdS based nano formulation. The foremost
objective of this study was to explore prospects of these nanoparticles as a potent anticancer agent.
Human ovarian teratocarcinoma cells (PA1) and human breast cancer cells (MDAMB-231) were tested
against these nanoparticles. Analysis by MTT assay showed cytotoxic effect on cell lines when treated
with increasing concentration of NPs. IC50 for 24 hour treatment was obtained as 97.34 μg/ml
and 809.75 μg/ml for ovarian and breast cancer cells respectively. Furthe.. View More»
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